No wonder we can’t resist dessert. We hate to diet because our brains are wired that way. Specifically, it is hunger-sensitive cells in the brain — known as AGRP neurons — that are responsible for creating those unpleasant feelings of hunger that so often lead us to fall off the diet wagon, according to scientists at the Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Virginia. To no one’s surprise, it is those negative emotions associated with hunger that make it so hard to maintain a diet and lose weight. While the AGRP neurons do not directly drive us to eat, they make us desire food so those unpleasant hunger pangs will go away. And it’s not just hunger. The Howard Hughes research team, led by Scott Sternson, also found a separate set of neurons in the brain that generate unpleasant feelings of thirst.